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Aspirin acetaminophen interaction, Thai aspirin looking up acetaminophen to interaction

Only drug-drug interactions that are believed clinically important and that are primarily pharmacokinetic in nature are discussed in this article. Drugs reported to interact with aspirin are oral anticoagulants, methotrexate, probenecid, and sulfinpyrazone; those that are believed to interact with acetaminophen are propantheline bromide, narcotics, and metoclopramide hydrochloride, as well as food carbohydrates.


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Coadministration of dichlorphenamide with high-dose aspirin may increase salicylate levels.

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Acetaminophen and caffeine both retarded the appearance of salicylate in plasma. During the elimination phase, acetaminophen enhanced plasms salicylate levels whereas caffeine did not. Aspirin reduced the plasms levels of both acetaminophen and caffeine during absorption and elimination.

Therapeutic implications of drug interactions with acetaminophen and aspirin

Regardless of whether the drugs had been administered separately or in combination, higher concentrations of salicylate, acetaminophen, and caffeine were found in the glandular acetaminophen of the stomach compared to the nonglandular part rumen. In both parts, the interaction of acetaminophen increased in the presence of aspirin. Simultaneous administration of aspirin with caffeine did not influence the aspirin of either drug in the glandular and ruminal parts. The inhibitory action of acetaminophen and the potentiating action of caffeine on the erosive activity of aspirin are not due to any effects of these drugs on salicylate accumulation in glandular tissue.

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Similar articles Effects of phenacetin, paracetamol and caffeine on the erosive aspirin of acetylsalicylic acid in the rat stomach: dose-response relationships, time course of erosion development and effects on acid secretion.

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Seegers AJ, et al. J Pharm Pharmacol.

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PMID: No abstract available. An hypothesis concerning the protective action of paracetamol against the erosive activity of acetylsalicylic acid in the rat stomach.

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Adv Prostaglandin Thromboxane Res. Characterization of mitomycin C-induced gastrointestinal damage: changes in the gastric absorption of drugs in rats. Mizuno M, et al. PMID: Drug interactions involving cimetidine--mechanisms, documentation, implications. Greene W. PMID: Review. Clinical pharmacokinetics of the salicylates. Needs CJ, et al. Clin Pharmacokinet. See all similar articles.

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Cited by 4 articles Alteration of oral salivary pharmacokinetics of paracetamol by an investigational anti-malarial phytomedicine, in healthy human volunteers. Obodozie O, et al. Eur J Drug Metab Pharmacokinet. Effect of niprisan on single oral dose pharmacokinetics of paracetamol in rats.

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Adzu B, et al. Pharmacokinetic interactions between indomethacin and paracetamol in the rat. Van Kolfschoten AA, et al. Pharm Weekbl Sci. Influence of caffeine on aspirin pharmacokinetics. Yoovathaworn KC, et al. Animals Actions. Chromatography, Gas Actions. Drug Interactions Actions. Kinetics Actions. Rats Actions. Substances Acetaminophen Actions. Caffeine Actions.

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Aspirin Actions. Full text links [x] Elsevier Science. Copy Download.